Oral Cancer: From Prevention to Intervention

by Peter Thomson (Autor)

This is a concise, informed and practical manual detailing the cause, prevention and interventional treatment of oral cancer â ” the deadliest of oral diseases. In the 21st century, oral
cancer remains a lethal and deforming disease exhibiting rising incidence of epidemic proportions, particularly in younger patients, and is of global significance with over 300,000 new cases
presenting each year. Despite advances in diagnosis and management, half of all patients die within five years. Even following successful initial treatment, long-term prognosis is
compromised by the presentation of advanced tumours and development of widespread, multi-focal disease throughout the mouth and upper aero-digestive tract. The transformation of normal mouth
lining into â ~potentially malignantâ (TM) and subsequently malignant tissue is a complex, multistep and multifactorial process in which accumulated genetic alterations, often instigated by
overuse of tobacco and alcohol, disrupt the normal functioning of oral epithelial cells. Unfortunately, there is considerable public ignorance regarding oral cancer, and it is imperative for
disease prevention to raise awareness of the causes and symptoms of the disease, especially in those populations most â ~at-riskâ (TM) of cancer. This book provides pragmatic strategies to
improve both prevention and treatment intervention. Spanning nearly 40 years of clinical investigation, it reviews the biological basis of oral cancer, outlines primary, secondary and
tertiary preventive strategies and describe a pragmatic treatment intervention protocol that specifically utilizes the â ~potentially malignant windowâ (TM) to identify malignant disease at
the earliest possible stage and intervention to â ~stop the oral cancer clockâ (TM) and halt the progression of this deadliest of oral diseases.

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