This book explores, in a comprehensive and systematic manner, Surgical Research methodologies to the design and development of investigational studies in the field of implant-based oral rehabilitation. Such studies are linked in a chain binding in vitro, in vivo, ex vivo, and digital evaluations. An ambitious objective consists in exposing how investigators can generate and deliver knowledge by capturing synergy coming from preclinical and clinical trials. Accordingly, throughout the book, translational aspects are closely scrutinized. The opening chapters consider materials, methods and procedures for preclinical and clinical studies in which approaches and models are extensively described. The focus then moves to the process by which application of histology, biomechanics, biomarkers, cellular/molecular biology, and imaging technologies lead to new results and consequently novel treatment concepts in implant dentistry, implant borne prosthetic rehabilitations and the replacement or regeneration of tissues. Finally, the exciting opportunities afforded by the digital world are addressed. This book shall be a valuable resource and time-saving tool for a wide audience of researchers, students, practitioners, and academics.